luteinizing hormone; lutropin (LH)

Function

• carbohydrate sulfotransferase (CHST8, CHST9) required for biosynthesis of luteinizing hormone
• secreted in bursts in direct response to each pulse of GnRH from the hypothalamus
• binds to LH-receptor on surface of Leydig cells of the testes
• evokes secretion of testosterone & estradiol from Leydig cells

Pathology

• gene mutations in beta subunit (LH-beta):
  • female patients present with amenorrhea
  • no androgen precursors are produced by theca cells

Pharmacokinetics

• plasma 1/2 life is 20-30 minutes

1/2life = 20-30 min

More general terms

• pituitary gonadotropin
• multisubunit protein

More specific terms

• lutropin alpha (Luveris)

Additional terms

• carbohydrate sulfotransferase 8; galNAc-4-O-sulfotransferase 1; galNAc-4-ST1; galNAc4ST-1; N-acetylgalactosamine-4-O-sulfotransferase 1 (CHST8)
• gonadotropin-releasing hormone/factor; gonadoliberin; LH/FSH-releasing hormone (GnRH, LHRH)
• Leydig cell
• luteinizing hormone (LH) in serum
• Lutropin-choriogonadotropic hormone receptor; LH/CG-R; LSH-R; Luteinizing hormone receptor; LHR (LHCGR, LCGR, LGR2 LHRHR)
• menotropins (Pergonal, Repronex)
• pituitary adenoma/LH secreting

Component of

• follicle stimulating hormone/luteinizing hormone
• menotropins (Pergonal, Repronex)