gonadotropin-releasing hormone/factor; gonadoliberin; LH/FSH-releasing hormone (GnRH, LHRH)
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Function
- stimulates LH & FSH secretion from the anterior pituitary
- pulsatile secretion is essential for activity of GnRH
- increased frequency of GnRH pulses occurs during the early follicular phase of the menstrual cycle
- binds with high affinity to LH receptors & FSH receptors on pituitary gonadotrophs resulting in activation of phospholipase C
- suggested to have anti-aging and anti-inflammatory properties[3]
Structure
Compartment
Expression
- secreted in a pulsatile fashion from the hypothalamus
Pharmacology
- continuous stimulation with long-acting GnRH agonists (goserelin, gonadorelin) effectively castrates men with prostate cancer
Pharmacokinetics
- its half-life (2-4 min) is short
More general terms
More specific terms
- gonadotropin-releasing hormone/factor 1; gonadoliberin 1; LH/FSH-releasing hormone 1; gonadorelin (GnRH1, LHRH-1)
- gonadotropin-releasing hormone/factor; gonadoliberin 2; LH/FSH-releasing hormone 2 (GnRH2, LHRH2)
Additional terms
- follicle-stimulating hormone; follitropin (FSH)
- gonadotropin-releasing hormone [GNRH] receptor
- hypothalamus
- LHRH deficiency (gonadotropin-releasing hormone deficiency)
- luteinizing hormone; lutropin (LH)
- menotropins (Pergonal, Repronex)
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
- ↑ Popat V and Cowan BD Gonadotropin-Releasing Hormone Deficiency in Adults http://emedicine.medscape.com/article/255152-overview
- ↑ 3.0 3.1 Zhang G, Li J, Purkayastha S, Tang Y Hypothalamic programming of systemic ageing involving IKK-beta, NF-kappaB and GnRH. Nature. 2013 May 1 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23636330
Gabuzda D and Yankner BA. Physiology: Inflammation links ageing to the brain. Nature 2013 May 9; 497:197. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23636321