gonadotropin-releasing hormone/factor 1; gonadoliberin 1; LH/FSH-releasing hormone 1; gonadorelin (GnRH1, LHRH-1)

Function

• stimulates secretion of gonadotropins
• it stimulates secretion of both LH & FSH

Structure

• decapeptide
• belongs to the GnRH family

Compartment

• GnRH1 is completely confined to the hypophyseal-portal blood supply

Expression

• secreted in a pulsatile fashion from the hypothalamus

Pharmacology

see Lutrepulse (Relisorm, Factrel)

More general terms

• gonadotropin-releasing hormone

Additional terms

• follicle-stimulating hormone; follitropin (FSH)
• gonadotropin-releasing hormone [GNRH] receptor
• hypothalamus
• luteinizing hormone; lutropin (LH)
• menotropins (Pergonal, Repronex)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2796
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2796
• OMIM: https://mirror.omim.org/entry/152760
• UniProt: http://www.uniprot.org/uniprot/P01148.html