gonadotropin-releasing hormone [GNRH] receptor

Function

• mediation of GnRH activity
• G-protein coupled
• isoform 2 may act as an inhibitor of GnRH-R signaling

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

integral membrane protein

Expression

• expressed in pituitary, ovary, testis, breast, prostate
• not expressed in liver, spleen

Pathology

• defects in GNRHR are a cause of
  • hypogonadotropic hypogonadism
  • fertile eunuch syndrome

Pharmacology

• GnRH analogs are used down-regulate the GnRH receptor in treatment of prostate cancer

More general terms

• G-protein coupled receptor; serpentine receptor

Additional terms

• gonadotropin-releasing hormone/factor; gonadoliberin; LH/FSH-releasing hormone (GnRH, LHRH)

Database

• UniProt: http://www.uniprot.org/uniprot/P30968.html
• OMIM: https://mirror.omim.org/entry/138850