follicle-stimulating hormone receptor; FSH-R; follitropin receptor (FSHR, LGR1)

Function

• receptor for follicle-stimulating hormone
• activity is mediated by G proteins which activate adenylate cyclase (Gs proteins)

Structure

• N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone (putative)
• belongs to the G-protein coupled receptor 1 family, FSH/LSH/TSH subfamily
• contains 10 LRR repeats (leucine-rich repeats)

Compartment

cell membrane

Alternative splicing

named isoforms=2

Expression

sertoli cells & ovarian granulosa cells

Pathology

• defects in FSHR are a cause of
  • ovarian dysgenesis 1
  • ovarian hyperstimulation syndrome
• activating mutations of the FSH receptor:
  • fertile eunuch syndrome

Laboratory

• FSHR gene mutation

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Additional terms

• follicle-stimulating hormone; follitropin (FSH)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2492
• OMIM: https://mirror.omim.org/entry/136435
• OMIM: https://mirror.omim.org/entry/233300
• OMIM: https://mirror.omim.org/entry/608115
• UniProt: http://www.uniprot.org/uniprot/P23945.html