Lutropin-choriogonadotropic hormone receptor; LH/CG-R; LSH-R; Luteinizing hormone receptor; LHR (LHCGR, LCGR, LGR2 LHRHR)

Function

• receptor for LH hormone
• activity is mediated by G proteins which activate adenylate cyclase
• activation results in secretion of testosterone & estradiol by Leydig cells & secretion of androstenedione (& other androgens) aromatized to estradiol by adjacent granulosa cells.

Structure

• belongs to the G-protein coupled receptor 1 family FSH/LSH/TSH subfamily
• contains 7 LRR repeats (leucine-rich repeats)

Compartment

cell membrane

Alternative splicing

named isoforms=2

Additional isoforms seem to exist

Expression

• expressed in gonadal & thyroid cells
• expressed by Leydig cells of the testes & theca cells of the ovary

Pathology

• defects in LHCGR are a cause of
  • familial male precocious puberty
  • Leydig cell hypoplasia

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Additional terms

• chorionic gonadotropin; choriogonadotropin (APL, hCG)
• luteinizing hormone; lutropin (LH)

Database

• OMIM: https://mirror.omim.org/entry/152790
• OMIM: https://mirror.omim.org/entry/176410
• UniProt: http://www.uniprot.org/uniprot/P22888.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3973