lactoperoxidase; salivary peroxidase; SPO (LPO, SAPX)

Function

• may contribute to airway host defense against infection

Donor + H2O2 = oxidized donor + 2 H2O

Cofactor:

• binds 1 Ca+2 per heterodimer (putative)
• binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer (putative)

Structure

belongs to the peroxidase family, XPO subfamily

Compartment

secreted, extracellular space

Expression

• mammary gland; milk & salivary gland
• found in bronchial submucosal glands

More general terms

• peroxidase
• milk protein
• Ca+2 binding protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4025
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4025
• OMIM: https://mirror.omim.org/entry/150205
• OMIM: https://mirror.omim.org/entry/170990
• UniProt: http://www.uniprot.org/uniprot/P22079.html