thioredoxin domain-containing protein 11 (EF-hand-binding protein 1, TXNDC11, EFP1)

Function

• may act as a redox regulator involved in DUOX proteins folding
• interaction with cytoplasmic part of DUOX1 & DUOX2
• may belong to a multiprotein complex constituting the thyroid H2O2 generating system; however not sufficient to assist DUOX1 & DUOX2 in H2O2 generation
• interacts with TPO & CYBA

Structure

• belongs to the protein disulfide isomerase family
• contains 2 thioredoxin domains

Compartment

endoplasmic reticulum

Alternative splicing

named isoforms=3

Expression

• widely expressed at low level
• expressed at higher level in thyroid & prostate

More general terms

• thioredoxin domain-containing protein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6PKC3.html