p67phox; neutrophil cytosol factor-2; NCF-2; neutrophil NADPH oxidase factor
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Function
- NCF2, NCF1, & a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production)
Structure
- contains 1 OPR domain
- contains 2 SH3 domains
- contains 3 TPR repeats
Compartment
Pathology
- defects in NCF2 are a cause of autosomal recessive chronic granulomatous disease
More general terms
Additional terms
Component of
References
- ↑ Rotrosen D, Yeung CL, Leto TL, Malech HL, Kwong CH. Cytochrome b558: the flavin-binding component of the phagocyte NADPH oxidase. Science. 1992 Jun 5;256(5062):1459-62. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1318579
- ↑ Segal AW, Abo A. The biochemical basis of the NADPH oxidase of phagocytes. Trends Biochem Sci. 1993 Feb;18(2):43-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8488557
- ↑ Pawson T Protein modules and signalling networks Nature 373:573 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7531822
- ↑ NCF2base; NCF2 deficiency database http://bioinf.uta.fi/NCF2base/
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=NCF2
- ↑ UniProt http://www.uniprot.org/uniprot/P19878.html