phospholipase-D1 (PLD1, choline phosphatase 1, phosphatidylcholine-hydrolyzing phospholipase D1, hPLD1)

Function

• implicated in numerous cellular pathways, including signal transduction, membrane trafficking, & regulation of mitosis
• role in regulation of perinuclear intravesicular membrane traffic (putative)
• interacts with PIP5K1A
• stimulated by phosphatidylinositol 4,5-bisphosphate & phosphatidylinositol 3,4,5-trisphosphate
• activated by phosphokinase C-alpha, ADP-ribosylation factor-1 (ARF-1), & to a lesser extent by GTP-binding proteins: RHO-A, RAC-1 & CDC42.
• inhibited by oleate

phosphatidylcholine + H2O <--> choline + a phosphatidate

Structure

• belongs to the phospholipase D family
• contains 1 PH domain
• contains 2 PLD phosphodiesterase domains
• contains 1 PX (phox homology) domain

Compartment

• cytoplasm, perinuclear region
• endoplasmic reticulum (putative)
• Golgi (putative)
• late endosome

Alternative splicing

named isoforms=4

Expression

• expressed abundantly in pancreas & heart & at high levels in brain, placenta, spleen, uterus & small intestine

More general terms

• phospholipase-D (PLD)

Additional terms

• ceramide

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5337
• OMIM: https://mirror.omim.org/entry/602382
• UniProt: http://www.uniprot.org/uniprot/Q13393.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5337