myozenin-3 (calsarcin-3, FATZ-related protein 3, MYOZ3, FRP3)

Function

• myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP & localizing calcineurin signaling to the sarcomere
• role in modulation of calcineurin signaling
• may play a role in myofibrillogenesis
• interacts with ACTN2, LDB3, FLNC, PPP3CA & TCAP

Structure

belongs to the myozenin family

Compartment

localized at the Z-line of skeletal muscle (putative)

Alternative splicing

named isoforms=3

Expression

• expressed specifically in skeletal muscle
• not detected in heart

More general terms

• myozenin (MYOZ)

Database

• UniProt: http://www.uniprot.org/uniprot/Q8TDC0.html