transcription factor AP-2 beta (AP2-beta, activating enhancer-binding protein 2 beta, TFAP2B)

Function

• sequence-specific DNA-binding protein
• interacts with inducible viral & cellular enhancer elements to regulate transcription of selected genes
• AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' & activate genes involved in a large spectrum of biological functions including eye, face, body wall, limb & neural tube development
  • also suppress genes including MCAM/MUC18, C/EBP alpha & MYC
• AP-2 beta appears to be required for normal face & limb development & for terminal differentiation of renal tubular epithelia
• binds DNA as a dimer
• can form homodimers or heterodimers with other AP-2 family members
• interacts with CITED4, UBE2I
• sumoylation on Lys-10 inhibits transcriptional activity

Structure

• belongs to the AP-2 family

Compartment

nucleus

Alternative splicing

named isoforms=2

Pathology

• defects in TFAP2B are the cause of Char syndrome

More general terms

• DNA-binding protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/169100
• OMIM: https://mirror.omim.org/entry/601601
• UniProt: http://www.uniprot.org/uniprot/Q92481.html