activating protein 2 (AP2)

Function

• sequence-specific DNA-binding proteins that interact with inducible viral & cellular enhancer elements to regulate transcription of selected genes
• AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' & activate genes involved in a large spectrum of biological functions including proper eye, face, body wall, limb & neural tube development
• AP-2 factors also suppress a number of genes including MCAM/MUC18, C/EBP alpha & MYC (putative)
• AP-2 factor bind DNA as a dimer

More general terms

• transcription factor (TF)
• DNA-binding protein

More specific terms

• transcription factor AP-2 delta (AP2-delta, activating enhancer-binding protein 2 delta, transcription factor AP-2 beta-like 1, TFAP2D, TFAP2BL1)
• transcription factor AP-2 epsilon (AP2-epsilon, activating enhancer-binding protein 2 epsilon, TFAP2E)
• transcription factor AP-2 gamma; AP2-gamma; activating enhancer-binding protein 2 gamma; transcription factor ERF-1 (TFAP2C)
• transcription factor AP-2-alpha; AP2-alpha; AP-2 transcription factor; activating enhancer-binding protein 2-alpha; activator protein 2 (TFAP2A, AP2TF, TFAP2)
• transcription factor AP-2-delta; AP2-delta; activating enhancer-binding protein 2-delta; transcription factor AP-2-beta-like 1 (TFAP2D, TFAP2BL1)