transcription factor AP-2-delta; AP2-delta; activating enhancer-binding protein 2-delta; transcription factor AP-2-beta-like 1 (TFAP2D, TFAP2BL1)

Function

• sequence-specific DNA-binding protein
• interacts with inducible viral & cellular enhancer elements to regulate transcription of selected genes
• AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' & activate genes involved in a large spectrum of biological functions including proper eye, face, body wall, limb & neural tube development
• AP-2 factors also suppress a number of genes including MCAM/MUC18, C/EBP alpha & MYC (putative)
• binds DNA as a dimer
• can form homodimers or heterodimers with other AP-2 family members (putative)

Structure

belongs to the AP-2 family

Compartment

nucleus (probable)

Expression

• expressed in brain, placenta, skeletal muscle, thymus, small intestine, & prostate > leukocyte, spleen, testis, ovary & colon > heart, kidney, liver, lung or pancreas

More general terms

• activating protein 2 (AP2)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=83741
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:83741
• OMIM: https://mirror.omim.org/entry/610161
• UniProt: http://www.uniprot.org/uniprot/Q7Z6R9.html