transcription factor AP-2 gamma; AP2-gamma; activating enhancer-binding protein 2 gamma; transcription factor ERF-1 (TFAP2C)

Function

• sequence-specific DNA-binding protein
• interacts with inducible viral & cellular enhancer elements to regulate transcription of selected genes
• AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' & activate genes involved in a large spectrum of biological functions
• AP-2 factors also suppress a number of genes including MCAM/MUC18, C/EBP alpha & MYC
• binds DNA as a dimer
• can form homodimers or heterodimers with other AP-2 family members (putative)
• interacts with WWOX
• interacts with CITED4
• interacts with UBE2I
• sumoylated on Lys-10; which inhibits transcriptional activity

Structure

• WW-binding motif mediates interaction with WWOX
• belongs to the AP-2 family

Compartment

nucleus (probable)

Expression

during retinoic acid-mediated differentiation

More general terms

• activating protein 2 (AP2)
• oligomerizing protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7022
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7022
• OMIM: https://mirror.omim.org/entry/601602
• UniProt: http://www.uniprot.org/uniprot/Q92754.html