Cbp/p300-interacting transactivator 4 (MSG1-related protein 2, MRG-2, CITED4 MRG2)

Function

• transcriptional coactivator for TFAP2/AP-2
• inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP (putative)
• role in regulation of gene expression during development & differentiation of blood cells, endothelial cells & mammary epithelial cells
• interacts via its C-terminal region with the CH1 domain of CREBBP & EP300
• interacts with all TFAP2/AP-2 isoforms

Structure

• belongs to the CITED family

Compartment

nucleus, cytoplasm

Expression

• expressed in most tissues
• highest levels of expression in heart, liver, skeletal muscle, pancreas

Pathology

• expressed in bladder cell line ECV304 & in various breast cancer cell lines
• expression is down-regulated & mostly restricted to the cytoplasm of malignant epithelium in invasive breast tumors
• down-regulation of expression is associated with elevated levels of HIF1A and increased tumor growth & angiogenesis

More general terms

• transcription factor (TF)

Database

• OMIM: https://mirror.omim.org/entry/606815
• UniProt: http://www.uniprot.org/uniprot/Q96RK1.html