ets1 proto-oncogene protein; protein C-ets-1; p54 (ETS1, EWSR2)
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Function
- transcription factor
- binds to DAXX
- interacts with UBE2I
- sumoylated on Lys-15 & Lys-227, preferentially by SUMO2 which inhibits transcriptional activity (putative)
- ubiquitinated; which induces proteasomal degradation
Structure
- belongs to the ETS family
- contains 1 ETS DNA-binding domain
- contains 1 PNT (pointed) domain
Compartment
Alternative splicing
named isoforms=2
Expression
- elevated expression in thymus & endothelial cells
- positively autoregulates transcription of its gene
Pathology
- ETS is responsible for erythroblast & fibroblast transformation
- juxtaposition of the interferon & c-ETS-1 proto-oncogene may be involved in the pathogenesis of monocytic leukemia
More general terms
More specific terms
References
- ↑ Ho IC, Bhat NK, Gottschalk LR, Lindsten T, Thompson CB, Papas TS, Leiden JM. Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene enhancer. Science. 1990 Nov 9;250(4982):814-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2237431
- ↑ Macleod K, Leprince D, Stehelin D. The ets gene family. Trends Biochem Sci. 1992 Jul;17(7):251-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1502727
- ↑ Bories JC et al Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature. 1995 Oct 19;377(6550):635-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7566176
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2113