SUMO-activating enzyme subunit 2; anthracycline-associated resistance ARX; ubiquitin-like 1-activating enzyme E1B (UBA2 SAE2 UBLE1B HRIHFB2115)

Function

• heterodimer of SAE1 & UBA2/SAE2 acts as a E1 ligase for SUMO1, SUMO2, SUMO3, & probably SUMO4
• enzyme catalytic subunit
• mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein & a conserved active site Cys on UBA2/SAE2
• protein modification; protein sumoylation
• heterodimer of SAE1 & UBA2/SAE2 corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1
• interacts with UBE2I

Structure

belongs to the ubiquitin-activating E1 family

Compartment

nucleus

Expression

• expression induced by c-Myc

Laboratory

• SUMO-activating enzyme subunit 2 Ab in serum

Notes

• SAE2 inhibition switches a transcriptional subprogram of c-Myc from activated to repressed
• AE2 inhibition produces defects in the mitotic spindles of cancerous cells triggered to divide by c-Myc activation

More general terms

• enzyme catalytic subunit
• nuclear protein
• phosphoprotein

Additional terms

• small ubiquitin-related modifier 1; SUMO-1; sentrin; ubiquitin-like protein SMT3C; SMT3 homolog 3; ubiquitin-homology domain protein PIC1; ubiquitin-like protein UBL1; GAP-modifying protein 1; GMP1 (SUMO1, SMT3C, SMT3H3, UBL1, OK/SW-cl43)

Component of

• ubiquitin-like 1 [UBL1] activating enzyme E1 (SUMO-1 activating enzyme, UBLE1 ligase)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10054
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10054
• OMIM: https://mirror.omim.org/entry/613295
• UniProt: http://www.uniprot.org/uniprot/Q9UBT2.html