ubiquitin-like 1 [UBL1] activating enzyme E1 (SUMO-1 activating enzyme, UBLE1 ligase)

Function

• acts as a E1 ligase for SUMO1, SUMO2, SUMO3, & probably SUMO4
• mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein & a conserved active site Cys on UBA2/SAE2
• protein modification; protein sumoylation

Structure

• heterodimer of SAE1 & UBA2/SAE2 corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1

Pathology

• low levels of UBLE1 ligase in human breast cancer with activated c-Myc correlate with better survival

More general terms

• ligase or synthetase
• molecular complex

Additional terms

• small ubiquitin-related modifier 1; SUMO-1; sentrin; ubiquitin-like protein SMT3C; SMT3 homolog 3; ubiquitin-homology domain protein PIC1; ubiquitin-like protein UBL1; GAP-modifying protein 1; GMP1 (SUMO1, SMT3C, SMT3H3, UBL1, OK/SW-cl43)