human herpesvirus type 6; roseolovirus (HHV-6)
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Classification
- apparently subtypes A & B[3]
Epidemiology
- ~1% of humans have inherited the genomes of HHV-6 (HHV-6A & HHV-6B)
Pathology
- virus latent in T-cells
- subtype A (HHV-6A) may play a role in unexplained female infertility[3]
- fetal inheritance of chromosomally integrated human herpesvirus 6 predisposes mother to pre-eclampsia[6]
- HHV6A may affect metabolism of beta-amyloid precursor protein in brain[5]
- HHV-6A/HHV-6B increases risk for systemic lupus erythematosus & pulmonary alveolar proteinosis disease activity[7]
- HHV-6A/HHV-6B increases risk for angina pectoris[7][8]
Clinical manifestations
- mononucleosis-like syndrome
- 6th disease in children
- may affect various organs in tranplant patients
- menigoencephalitis in a stem-cell transplant patient[4] (case report)
Laboratory
- Herpesvirus type 6 serology
- Herpesvirus type 6 DNA
- see ARUP consult[2]
More general terms
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 11, 17, 18. American College of Physicians, Philadelphia 1998, 2015, 2018
- ↑ 2.0 2.1 ARUP Consult: Herpesvirus 6 - HHV6 The Physician's Guide to Laboratory Test Selection & Interpretation https://www.arupconsult.com/content/human-herpesvirus-6
- ↑ 3.0 3.1 3.2 Marci R, Gentili V, Bortolotti D et al Presence of HHV-6A in Endometrial Epithelial Cells from Women with Primary Unexplained Infertility. PLoS One. 2016 Jul 1;11(7):e0158304. eCollection 2016. PMID: https://pubmed.ncbi.nlm.nih.gov/27367597 Free PMC Article
- ↑ 4.0 4.1 El-Jawahri AR, Schaefer PW, El Khoury JB, Martinez-Lage M. Case 5-2018: A 63-Year-Old Man with Confusion after Stem-Cell Transplantation. N Engl J Med 2018; 378:659-669 <PubMed> PMID: https://pubmed.ncbi.nlm.nih.gov/29443669 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMcpc1707556
- ↑ 5.0 5.1 Readhead B, Haure-Mirande JV, Funk CC et al Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus. Neuron. June 2018. PMID: https://pubmed.ncbi.nlm.nih.gov/29937276 https://www.cell.com/neuron/fulltext/S0896-6273(18)30421-5
- ↑ 6.0 6.1 Gaccioli F, Lager S, de Goffau MC et al. Fetal inheritance of chromosomally integrated human herpesvirus 6 predisposes the mother to pre-eclampsia. Nat Microbiol 2020 May 4 PMID: https://pubmed.ncbi.nlm.nih.gov/32367053 https://www.nature.com/articles/s41564-020-0711-3
- ↑ 7.0 7.1 7.2 Sasa N et al. Blood DNA virome associates with autoimmune diseases and COVID-19. Nat Genet 2025 Jan; 57:65. PMID: https://pubmed.ncbi.nlm.nih.gov/39753770 PMCID: PMC11735405
- ↑ 8.0 8.1 Wood ML et al. Inherited chromosomally integrated human herpesvirus 6: Regional variation in prevalence, association with angina, and identification of ancestral viral lineages in two large UK studies. J Virol 2025 Jul 22; 99:e0216024 PMID: https://pubmed.ncbi.nlm.nih.gov/40470957 PMCID: PMC12282103 https://journals.asm.org/doi/10.1128/jvi.02160-24
Gravel A, Dubuc I, Morissette G, Sedlak RH, Jerome KR, Flamand L. Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris. Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8058-63. PMID: https://pubmed.ncbi.nlm.nih.gov/26080419 PMCID: PMC4491735 Free PMC article. https://www.pnas.org/doi/full/10.1073/pnas.1502741112