ran GTPase-activating protein1 (ranGAP1)

Function

• GAP activity specific for ran protein
• sumoylated by SUMO1
• sumoylation leads to association of
• RanGAP1 with the nuclear envelope (NE) (putative)

Structure

• homodimer
• forms a tight complex in association with RANBP2 & the ubiquitin-conjugating enzyme E2 (UBC9)
• belongs to the RNA1 family
• contains 6 LRR repeats (leucine-rich repeats)

Compartment

cytoplasm

Expression

• highly expressed in brain, thymus & testis

More general terms

• GTPase-activating protein (GAP)
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/602362
• UniProt: http://www.uniprot.org/uniprot/P46060.html