glutathione [GSH] synthetase (GSS)

Function

• sulfur metabolism; glutathione biosynthesis;
• glutathione from L-cysteine & L-glutamate: step 2/2

ATP + gamma-L-glutamyl-L-cysteine + glycine
               <-->
ADP + phosphate + glutathione

Structure

• homodimer (putative)
• belongs to the eukaryotic GSH synthase family

Pathology

• defects in GSS are the cause of glutathione synthetase deficiency

More general terms

• ligase or synthetase

Additional terms

• gamma glutamyl cycle
• glutathione; gamma-glutamylcysteinylglycine (GSH)

Database

• OMIM: https://mirror.omim.org/entry/231900
• OMIM: https://mirror.omim.org/entry/266130
• OMIM: https://mirror.omim.org/entry/601002
• UniProt: http://www.uniprot.org/uniprot/P48637.html