gamma glutamyl cycle

Introduction

see figure

Biochemistry

• gamma-glutamyl cycle 1
  • enzyme: gamma-glutamyl cysteine synthetase
  • substrate: cysteine + glutamate + ATP
  • product: gamma-glutamylcysteine + ADP + H2PO4-
• gamma-glutamyl cycle 2
  • enzyme: glutathione synthetase
  • substrate: gamma-glutamylcysteine + glycine + ATP
  • product: glutathione + ADP + H2PO4-
• gamma-glutamyl cycle 3
  • enzyme: gamma-glutamyltransferase (plasma membrane)
  • substrate: glutathione + amino acid (extracellular))
  • product: gamma-glutamyl-amino acid (intracellular) + cysteinylglycine
• gamma-glutamyl cycle 4
  • enzyme: gamma-glutamylcyclotransferase
  • substrate: gamma-glutamyl-amino acid
  • product: 5-oxoproline
• gamma-glutamyl cycle 5
  • enzyme: 5-oxoprolinase
  • substrate: 5-oxoproline + ATP + H2O
  • product: glutamate + ADP + H2PO4-
• gamma-glutamyl cycle 6
  • enzyme: dipeptidase
  • substrate: cysteinylglycine + H2O
  • product: cysteine + glycine

More general terms

• molecular pathway