5-oxoprolinase (OPLAH, 5-oxo-L-prolinase, pyroglutamase, pyroglutamate aminopeptidase, pyrrolidonecarboxylate peptidase, OPLAH)

Function

• cleaves 5-oxoproline to form L-glutamate coupled to hydrolysis of ATP in gamma glutamyl cycle

ATP + 5-oxo-L-proline + 2 H2O <--> ADP + phosphate + L-glutamate

Structure

• homodimer
• belongs to the oxoprolinase family

More general terms

• aminopeptidase

Additional terms

• 5 oxoproline
• gamma glutamyl cycle

Database

• OMIM: https://mirror.omim.org/entry/260005
• UniProt: http://www.uniprot.org/uniprot/O14841.html