phosphoribosylformylglycinamidine synthase; FGAM synthase; FGAMS; formylglycinamide ribotide amidotransferase; FGARAT; formylglycinamide ribotide synthetase (PFAS, KIAA0361)

Function

• purine metabolism; IMP biosynthesis via de novo pathway 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2

ATP + N(2)-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O

<-->

ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate

Structure

• in the N-terminal section; belongs to the FGAMS family
• contains 1 glutamine amidotransferase type-1 domain

Compartment

cytoplasm (putative)

More general terms

• amidotransferase
• ligase or synthetase
• phosphoprotein

Additional terms

• ornithine decarboxylase 1

Database

• OMIM: https://mirror.omim.org/entry/602133
• UniProt: http://www.uniprot.org/uniprot/O15067.html