5-formyltetrahydrofolate cyclo-ligase; 5,10-methenyl-tetrahydrofolate synthetase; methenyl-THF synthetase (MTHFS)

Function

-..........-

ATP + 5-formyltetrahydrofolate
       <-->
ADP + phosphate + 5,10-methenyltetrahydrofolate

Cofactor: Mg+2

Structure

• monomer
• belongs to the 5-formyltetrahydrofolate cyclo-ligase family

Compartment

cytoplasm

More general terms

• ligase or synthetase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10588
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10588
• OMIM: https://mirror.omim.org/entry/604197
• UniProt: http://www.uniprot.org/uniprot/P49914.html