solute carrier family 27 member 5 (SLC27A5, long-chain fatty acid transport protein 5, bile acyl-CoA synthetase, BACS, bile acid CoA ligase, BA-CoA ligase, BAL, cholate-CoA ligase, very long-chain acyl-CoA synthetase homolog 2, VLCSH2, VLCS-H2, very long chain acyl-CoA synthetase-related protein, VLACS-related, VLACSR, fatty-acid-coenzyme A ligase, very long-chain 3, fatty acid transport protein 5, FATP-5)

Function

• acyl-CoA synthetase involved in bile acid metabolism
• catalyzes 1st step in the conjugation of C24 bile acids (choloneates) to glycine & taurine before excretion into bile canaliculi by activating them to their CoA thioesters
• seems to activate secondary bile acids entering the liver from the enterohepatic circulation
• in vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy- 5-beta-cholestanate (THCA), the C27 precursor of cholic acid derived from de novo synthesis from cholesterol

ATP + cholate + CoA <--> AMP + diphosphate + choloyl-CoA

ATP + (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oate + CoA
                              <-->  AMP + diphosphate + (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA

Structure

• belongs to the ATP-dependent AMP-binding enzyme family

Compartment

endoplasmic reticulum membrane

Expression

predominantly expressed in liver

More general terms

• transmembrane 3 protein
• ligase or synthetase
• solute carrier family 27 (SLC27, SLC27A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1099
• OMIM: https://mirror.omim.org/entry/603314
• UniProt: http://www.uniprot.org/uniprot/Q9Y2P5.html