solute carrier family 27 member 4 (SLC27A4, long-chain fatty acid transport protein 4, fatty acid transport protein 4, FATP-4, ACSVL4, FATP4)

Function

• involved in translocation of long-chain fatty acids across the plasma membrane
• principal fatty acid transporter in small intestinal enterocytes
• role in the formation of the epidermal barrier
• acyl-CoA ligase activity for
  • long-chain fatty acids
  • very long-chain fatty acids

Structure

• belongs to the ATP-dependent AMP-binding enzyme family

Compartment

membrane (probable)

Expression

• expressed in brain, testis, colon & kidney > heart & liver, small intestine & stomach > peripheral blood leukocytes, bone marrow, skeletal muscle & aorta
• expressed in adipose tissue

Pathology

• SLC27A4/FATP4-mediated fatty acid uptake is associated with parameters related to:
  • insulin resistance
  • fatty acid metabolism & homeostasis
  • obesity
• SLC27A4/FATP4 expression is positively correlated with aquired obesity

More general terms

• solute carrier family 27 (SLC27, SLC27A)
• transmembrane 2 protein
• ligase or synthetase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1099
• OMIM: https://mirror.omim.org/entry/604194
• UniProt: http://www.uniprot.org/uniprot/Q6P1M0.html