E3 SUMO-protein ligase NSE2 (non-structural maintenance of chromosomes element 2 homolog, non-SMC element 2 homolog, hMMS21, NSMCE2, C8orf36, MMS21)

Function

• E3 SUMO-protein ligase component of the SMC5-SMC6 complex
• acts as a E3 ligase mediating SUMO attachment to various proteins including SMC6L1 & TRAX, & perhaps the cohesin components RAD21 & STAG2
• SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair
• SUMO conjugation, 3rd step
• sumoylated, possibly via autosumoylation

Structure

• belongs to the NSE2 family
• contains 1 SP-RING-type zinc finger

Compartment

nucleus (probable)

More general terms

• ring finger protein
• ligase or synthetase
• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96MF7.html