cohesin subunit SA-2; SCC3 homolog 2; stromal antigen 2 (STAG2, SA2)

Function

• component of cohesin complex
• phosphorylated by PLK.
• dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (putative)
• interacts directly with RAD21 in cohesin complex
• in cohesin complexes, STAG2 is mutually exclusive with STAG1 & STAG3

Structure

• belongs to the SCC3 family
• contains 1 SCD (stromalin conservative) domain

Compartment

• nucleus, chromosome, centromere
• associates with chromatin
• before prophase, it is scattered along chromosome arms
• during prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain
• at anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation
• in germ cells, cohesin complex dissociates from chromatin at prophase 1, & may be replaced by a meiosis-specific cohesin complex

More general terms

• stromal antigen (STAG)
• nuclear protein
• phosphoprotein

Component of

• cohesion complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10735
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10735
• OMIM: https://mirror.omim.org/entry/604359
• UniProt: http://www.uniprot.org/uniprot/Q8N3U4.html