structural maintenance of chromosomes protein 6 (hSMC6, SMC6, SMC6L1)

Function

• core component of the SMC5-SMC6 complex
• forms a heterodimer with SMC5
• phosphorylated
• sumoylated by NSMCE2/MMS21

Structure

• flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V-shaped heterodimer (putative)
• belongs to the SMC family, SMC6 subfamily

Compartment

• nucleus
• associates with chromatin

Alternative splicing

named isoforms=2

Expression

• widely expressed
• overexpressed in testis

More general terms

• structural maintenance of chromosomes protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96SB8.html