structural maintenance of chromosomes protein 5 (hSMC5, SMC5, KIAA0594, SMC5L1)

Function

• core component of the SMC5-SMC6 complex
• forms a heterodimer with SMC6

Structure

• flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC6, forming a V-shaped heterodimer (putative)
• belongs to the SMC family, SMC5 subfamily

Compartment

• nucleus
• associates with chromatin

Expression

widely expressed

More general terms

• structural maintenance of chromosomes protein

Component of

• SMC5-SMC6 complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IY18.html