tRNA-splicing ligase RtcB homolog (RTCB, C22orf28, HSPC117)

Function

• catalytic subunit of the tRNA-splicing ligase complex
• acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into mature tRNA as a canonical 3',5'-phosphodiester
• may act as a RNA ligase with broad substrate specificity

ATP + (ribonucleotide)(n) + (ribonucleotide)(m) = AMP + diphosphate + (ribonucleotide)(n+m)

Structure

belongs to the RtcB family

Compartment

cytoplasm (putative)

More general terms

• enzyme catalytic subunit
• ligase or synthetase
• metalloprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51493
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51493
• OMIM: https://mirror.omim.org/entry/613901
• UniProt: http://www.uniprot.org/uniprot/Q9Y3I0.html