multifunctional protein ADE2; phosphoribosylaminoimidazole succinocarboxamide synthase; SAICAR synthetase; phosphoribosylaminoimidazole carboxylase (ADE2, AIRC, PAICS, PAIS)

Function

• purine metabolism; IMP biosynthesis via de novo pathway
• 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 3/5
• purine metabolism; IMP biosynthesis via de novo pathway
• 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 4/5

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate
       <-->
ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate (SAICAR)

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
         <-->
5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2

Structure

• homooctamer
• synthetase family
• carboxylase family

More general terms

• carboxy-lyase or decarboxylase
• ligase or synthetase
• multifunctional enzyme

Additional terms

• aminoimidazole carboxamide ribonucleotide; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (AICAR)
• succinylaminoimidazole carboxamide riboside (SAICAR)

Database

• UniProt: http://www.uniprot.org/uniprot/P22234.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10606
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1060
• OMIM: https://mirror.omim.org/entry/172439