interferon [IFN]-alpha 2; interferon [IFN]-alpha 3; IFN-alpha A; LEIF A (IFNA2)

Function

• antiviral activities
• interacts with IFNAR2

Structure

• belongs to the alpha/beta interferon family

Compartment

secreted

Expression

• expressed & secreted by macrophages

Polymorphism

• 3 forms exist; IFN alpha-2a, IFN alpha-2b & IFN alpha-2c

Pharmacology

• available under the names Roferon-A (Roche) or intron-A (Schering-Plough)
• used as an anti-neoplastic agent for its antiproliferative activity

More general terms

• interferon [IFN]-alpha

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3440
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3440
• OMIM: https://mirror.omim.org/entry/147562
• UniProt: http://www.uniprot.org/uniprot/P01563.html