lymphocyte antigen 96; Ly-96; ESOP-1; protein MD-2 (LY96, ESOP1 MD2)

Function

• cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS)
• cooprerates with TLR2 in the response to cell wall components Gram-positive & Gram-negative bacteria
• enhances TLR4-dependent activation of NF-kappa-B
• component of lipopolysaccharide receptor (LPS receptor)
• cells expressing both MD2 & TLR4, but not TLR4 alone, respond to LPS
• binds to the extracellular domains of TLR2 & TLR4
  • ligand binding induces interaction with TLR4 & oligomerization of the LPS receptor complex

Structure

• heterogeneous homopolymer formed from homodimers, disulfide-linked
• N-glycosylated, high-mannose

Compartment

secreted

More general terms

• secreted protein
• glycoprotein

Additional terms

• Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; CD282 (TLR2, TIL4)
• Toll-like receptor 3; CD283 (TLR3)

Component of

• lipopolysaccharide (LPS) receptor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23643
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23643
• OMIM: https://mirror.omim.org/entry/605243
• UniProt: http://www.uniprot.org/uniprot/Q9Y6Y9.html