Toll-like receptor 3; CD283 (TLR3)

Function

• innate immune response to microbial agents
• recognition of dsRNA of viral origin (putative)
  • binding of ds-RNA is required for the interaction with SRC
• acts via MyD88 & TRAF6
  • NF-kappa-B activation
  • cytokine secretion
  • inflammatory response
• may attenuate allergic response
  • stimulation decreases allergen-induced BAL eosinophils
• binds MyD88 via their respective TIR domains
• interacts with TICAM1

Structure

• homodimer formation is triggered by ligand binding & is required for TLR3 signaling
• heavily N-glycosylated, except on that part of the surface of the ectodomain that is involved in ligand binding
• belongs to the Toll-like receptor family
• contains 22 LRR repeats (leucine-rich repeats)
• contains 1 TIR domain

Compartment

• endoplasmic reticulum membrane
• endosome membrane

Expression

• expressed at high level in placenta, pancreas > CD11c+ immature dendritic cells.
• only expressed in dendritic cells, NOT in other leukocytes

More general terms

• toll-like receptor
• phosphoprotein
• glycoprotein
• leucine-rich repeat-containing protein (LRRC)
• CD antigen

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7098
• OMIM: https://mirror.omim.org/entry/603029
• UniProt: http://www.uniprot.org/uniprot/O15455.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7098