CD14; monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein

Function

• monocyte differentiation antigen
• interacts with apoptotic cells triggering phagocytosis of monocytes/macrophages
• cooperates with MD-2 & TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS)
• acts via MyD88, TIRAP & TRAF6, leading to NF-kappa-B activation, cytokine secretion & the inflammatory response
• up-regulates cell surface molecules, including adhesion molecules
• component of lipopolysaccharide receptor

Structure

• contains 11 LRR repeats (leucine-rich repeats)

Compartment

cell membrane; lipid-anchor, GPI-anchor

Expression

• expressed strongly on the surface of monocytes
• macrophages ~90%
• Langerhans cells
• dendritic cells
• B cells
• granulocytes - weak, ~30%
• myeloid progenitors stain negatively with antibody

Pathology

• expressed in:
  • B cell CLL
  • follicular center cell lymphoma ~80%
  • diffuse large B cell lymphoma ~40%
  • AML-M4/M5 ~50-90%
  • AML-M0/, AML-M1, AML-M2, AML-M3, AML-M6, AML-M7 stain negatively with antibody

More general terms

• glypiated protein
• CD antigen

Component of

• lipopolysaccharide (LPS) receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:929
• OMIM: https://mirror.omim.org/entry/158120
• UniProt: http://www.uniprot.org/uniprot/P08571.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=929