Toll-like receptor 1; Toll/interleukin-1 receptor-like protein; TIL; CD281 (TLR1, KIAA0012)

Function

• innate immune response to microbial agents
• cooperates with TLR2
  • modulates response to microbial constituents
• acts via MyD88 & TRAF6
  • NF-kappa-B activation
  • cytokine secretion
  • inflammatory response
• binds TLR2 via their respective extracellular domains
• binds MyD88 via their respective TIR domains

Structure

• belongs to the Toll-like receptor family
• contains 8 LRR repeats (leucine-rich repeats)
• contains 1 TIR domain

Compartment

• cell membrane
• cytoplasmic vesicle
• phagosome, phagosome membrane

Expression

• ubiquitous
• expressed in spleen, ovary, peripheral blood leukocytes, thymus, small intestine

More general terms

• toll-like receptor
• glycoprotein
• leucine-rich repeat-containing protein (LRRC)
• CD antigen

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7096
• OMIM: https://mirror.omim.org/entry/601194
• UniProt: http://www.uniprot.org/uniprot/Q15399.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7096