Toll-like receptor 6; CD286 (TLR6)

Function

• innate immune response to Gram-positive bacteria & fungi
• acts via MyD88 & TRAF6
  • NF-kappa-B activation
  • cytokine secretion
  • inflammatory response
• recognizes pathogen antigens cooperatively with TLR2
  • mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2)
  • soluble tuberculosis factor (STF)
  • phenol-soluble modulin (PSM)
  • B. burgdorferi outer surface protein A lipoprotein (OspA-L)
• binds TLR2 via their respective extracellular domains
• binds MyD88 via their respective TIR domains

Structure

• belongs to the Toll-like receptor family
• contains 13 LRR repeats (leucine-rich repeats)
• contains 1 TIR domain

Compartment

• cell membrane
• cytoplasmic vesicle
• phagosome membrane

Expression

• expressed in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells, dermal microvessel endothelial cells

More general terms

• toll-like receptor
• leucine-rich repeat-containing protein (LRRC)
• glycoprotein
• CD antigen

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1033
• OMIM: https://mirror.omim.org/entry/605403
• UniProt: http://www.uniprot.org/uniprot/Q9Y2C9.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10333