integrin alpha-X/beta-2 (CD11c/CD18)

Function

• mediates cell-cell interaction during inflammatory responses
• especially important in monocyte adhesion & chemotaxis
• receptor for fibrinogen
  • recognizes the sequence G-P-R in fibrinogen
• receptor for the iC3b fragment of component-C3

Structure

• subunits: integrin alpha-X, integrin beta-2

Compartment

membrane

More general terms

• integrin
• complement-3b [C3b] receptor