cell division protein kinase 11A; PITSLRE serine/threonine protein kinase CDC2L2; cell division cycle 2-like protein kinase 2; galactosyltransferase-associated protein kinase p58/GTA (CDK11A, CDC2L2, CDC2L3, PITSLREB)
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Function
- appears to play multiple roles in cell cycle progression, cytokinesis & apoptosis
- the p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7
- the p58 isoform may act as a negative regulator of normal cell cycle progression
- phosphorylation at Thr-433 or Tyr-434 inactivates the enzyme; phosphorylation at Thr-580 activates it (putative)
- during apoptosis, induced by Fas or tumor necrosis factor, specific CKD11 p110 isoforms are cleaved by caspases to produce a protein (p110C) that contains the C-terminal kinase domain of the CDK11 proteins
- the cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1
- the p58 isoform but not the p110 isoform or p110C interacts with CCND3
- the p110 isoforms are found in large molecular weight complexes containing CCNL1 & SFRS7
Structure
- belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
- contains 1 protein kinase domain
Compartment
Alternative splicing
named isoforms=8
Alternative initiation
Expression
- expressed ubiquitously
- some evidence of isoform-specific tissue distribution
- the p58 isoform is specifically induced in G2/M phase of the cell cycle
Genetics
- uplicated gene
- CDK11A & CDK11B encode almost identical protein kinases of 110 kD that contain at their C-termini the open reading frame of a smaller 58 kD isoform which is expressed following IRES-mediated alternative initiation of translation
Notes
- also see CDK11B
- many references talk about 'p110 isoforms' but it is not yet known if this refers to CDK11A &/or CDK11B or one/some of the isoforms of each