cyclophilin G (peptidyl-prolyl cis-trans isomerase G, PPIase G, rotamase G, Clk-associating RS-cyclophilin, CARS-cyclophilin, CARS-Cyp, SR-cyclophilin, SRcyp, CASP10, PPIG)

Function

• accelerates folding of proteins
• catalyzes cis-trans isomerization of proline imidic peptide bonds
• pre-mRNA splicing (putative)
• cyclosporin A-sensitive.
• interacts with CLK1, PNN, phosphorylated C-terminal domain of RNA polymerase 2

Compartment

• nucleus, nucleoplasm, nuclear matrix
• colocalizes with RNA splicing factors at nuclear speckles

Expression

ubiquitous

More general terms

• cyclophilin
• chaperonin; chaperone

Database

• OMIM: https://mirror.omim.org/entry/606093
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9360
• UniProt: http://www.uniprot.org/uniprot/Q13427.html