transglutaminase-3 (tranglutaminase-E, E3, TGM3)

Function

• catalyzes the cross-linking of proteins & the conjugation of polyamines to proteins
• responsible for the later stages of cell envelope formation in the epidermis & the hair follicle

protein glutamine + alkylamine
               <-->
protein N(5)-alkylglutamine + NH3

Cofactor: binds 1 Ca+2 per subunit (putative)

Structure

• consists of two polypeptide chains, which are synthesized as a precursor form of a single polypeptide activated by proteolytic processing
• belongs to the transglutaminase superfamily transglutaminase family82 1993

More general terms

• transglutaminase
• regulatory molecule
• multisubunit protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q08188.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7053
• OMIM: https://mirror.omim.org/entry/600238
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7053