angiopoietin-1; ANG-1 (ANGPT1 KIAA0003)

Function

• binds & activates TIE2 receptor by inducing its Tyr phosphorylation
• implicated in endothelial developmental processes later & distinct from that of VEGF
• role in mediating reciprocal interactions between the endothelium & surrounding matrix & mesenchyme
• mediates blood vessel maturation & stability
• may play a role in early heart development

Structure

• glycosylated
• contains 1 fibrinogen C-terminal domain

Compartment

secreted

Pharmacology

• may have a therapeutic utility
  • specifically targeting tumor vasculature
  • promoting angiogenic processes in ischemic heart

More general terms

• angiopoietin
• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=284
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:284
• OMIM: https://mirror.omim.org/entry/601667
• UniProt: http://www.uniprot.org/uniprot/Q15389.html