small proline-rich protein 2B; SPR-2B (SPRR2B)

Function

• cross-linked envelope protein of keratinocytes
• keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase; results in the formation of an insoluble envelope beneath the plasma membrane

Structure

belongs to the cornifin (SPRR) family

Compartment

cytoplasm

Expression

• suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue & trachea
• expressed during differentiation of squamous cells
• induced by UV irradiation & carcinogenic agents
• expressed during squamous differentiation of epidermal keratinocytes

More general terms

• small proline-rich protein 2

Database

• UniProt: http://www.uniprot.org/uniprot/P35325.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6701
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6701
• OMIM: https://mirror.omim.org/entry/182268