protein Dr1; down-regulator of transcription 1; TATA-binding protein-associated phosphoprotein; negative cofactor 2-beta; NC2-beta (DR1)

Function

• association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated & basal transcription of class II genes
• this interaction precludes the formation of a transcription- competent complex by inhibiting the association of TFIIA &/or TFIIB with TBP
• can bind to DNA on its own
• heterodimer with DRAP1
• DR1 exists in solution as a homotetramer that dissociates during interaction with TBP & then, after complexing with TBP, reassociates at a slow rate, to reconstitute the tetramer
• interacts with NFIL3
• phosphorylation regulates its interaction with TBP
• not phosphorylated when bound to DRAP1

Structure

• belongs to the NC2 beta/DR1 family
• contains 1 histone-fold domain

Compartment

nucleus

More general terms

• phosphoprotein
• transcription factor (TF)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1810
• OMIM: https://mirror.omim.org/entry/601482
• UniProt: http://www.uniprot.org/uniprot/Q01658.html