nuclear factor interleukin-3 regulated protein (E4 promoter binding-protein 4, interleukin-3 promoter transcriptional activator, transcriptional activator NF-IL3A, interleukin-3 binding-protein 1, NFIL3, E4BP4, IL3BP1)

Function

• transcriptional regulator that recognizes & binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3' present in many cellular & viral promoters
• represses transcription from promoters with activating transcription factor (ATF) sites
• represses promoter activity in osteoblasts
• represses transcriptional activity of PER1
• represses transcriptional activity of PER2 via B-site on the promoter
• activates transcription from interleukin-3 promoter in T-cells
• competes for same consensus-binding site with PAR DNA-binding factors DBP, HLF & TEF
• component of circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock
• protects pro-B cells from programmed cell death
• binds DNA as a dimer
• interacts with DR1, PER2 & CRY2

Structure

• homodimer
• belongs to the NFIL3 family
• contains 1 bZIP domain

Compartment

nucleus

Expression

• expressed in bladder, stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow, muscle
• up-regulated by PHA or TPA

More general terms

• DNA-binding protein
• transcriptional silencer (transcriptional repressor)
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/605327
• UniProt: http://www.uniprot.org/uniprot/Q16649.html