hepatic leukemia factor (HLF)

Function

• binds DNA specifically as homodimer or heterodimer with other PAR factors

Structure

• belongs to the bZIP family, PAR subfamily
• contains 1 bZIP domain

Compartment

nucleus (probable)

Expression

• highly expressed in liver; lower levels in lung & kidney
• accumulates according to a robust circadian rhythm

Pathology

• chromosomal translocation t(17;19)(q22;p13.3) involving TCF3 with HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL)

More general terms

• basic leucine zipper (bZIP) family protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q16534.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3131
• OMIM: https://mirror.omim.org/entry/142385
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3131