Dr1-associated corepressor (Dr1-associated protein 1, negative cofactor 2 alpha, NC2 alpha, DRAP1)

Function

• association of DR1/DRAP1 heterodimer with TBP results in functional repression of both activated & basal transcription of class II genes (genes with TATA-box ???)
• interaction precludes formation of a transcription-competent complex by inhibiting association of TFIIA &/or TFIIB with TBP
• binds DNA
• heterodimer with DR1
• binds BTAF1
• phosphorylation diminishes DNA binding, but has no effect on heterodimerization & TBP binding

Structure

• contains 1 histone-fold domain

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• DNA-binding protein
• phosphoprotein
• transcriptional silencer (transcriptional repressor)

Database

• OMIM: https://mirror.omim.org/entry/602289
• UniProt: http://www.uniprot.org/uniprot/Q14919.html